Primary Identifier | MGI:109527 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 22064 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Acts upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Located in dendrite membrane and endomembrane system. Is expressed in brain; ganglia; genitourinary system; sensory organ; and skeletal muscle. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). PHENOTYPE: Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and femalesand increased cholesterol in males. [provided by MGI curators] |