Primary Identifier | MGI:3609260 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 504186 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within cholinergic synaptic transmission; detection of mechanical stimulus involved in sensory perception of sound; and inner ear morphogenesis. Predicted to be located in axon and perikaryon. Predicted to be part of transmembrane transporter complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. Orthologous to human CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit). PHENOTYPE: Homozygous mutation of this gene results in impaired synaptic function and integrity of the olivocochlear system. [provided by MGI curators] |