Primary Identifier | MGI:1860040 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 55992 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in cytoplasm. Is expressed in several structures, including adrenal gland; cardiovascular system; genitourinary system; gut gland; and nervous system. Orthologous to human TRIM3 (tripartite motif containing 3). PHENOTYPE: Mice homozygous for a null allele have decreased susceptibility to pharmacologically induced seizure as well as reduced miniature inhibitory synaptic current amplitude in cortical neurons. Mice homozygous for another null allele are viable and fertile. [provided by MGI curators] |