Primary Identifier | MGI:1924755 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 77505 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Is expressed in cartilage; central nervous system; genitourinary system; stomach; and trachea. Human ortholog(s) of this gene implicated in spermatogenic failure 65. Orthologous to human DNHD1 (dynein heavy chain domain 1). PHENOTYPE: Males homozygous for a null allele exhibit male infertility, reduced sperm numbers and sperm motility, and abnormalities of sperm flagella. [provided by MGI curators] |