| Primary Identifier | MGI:1298390 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 20947 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). PHENOTYPE: Homozygous mutation of this gene results in increased sensitivity of B lymphocytes to gamma-radiation, increased autoantibody levels, and lower IgE levels, both before and after immunization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
