| Primary Identifier | MGI:1338023 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17540 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within cGMP-mediated signaling and relaxation of vascular associated smooth muscle. Predicted to be located in membrane; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is expressed in bladder wall; cerebral cortex; gut; and liver lobe. Orthologous to human IRAG1 (inositol 1,4,5-triphosphate receptor associated 1). PHENOTYPE: Mice homozygous for a knock-out allele show lower blood pressure, a slightly reduced heart rate, and failure of cGMP-mediated relaxation of receptor-triggered smooth muscle contraction; 50% of mice die prematurely with an enlarged stomach, a dilated cecum, pyloric stenosis and impaired GI motility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
