Primary Identifier | MGI:2385287 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233744 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables LBD domain binding activity. Acts upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix. Is expressed in several structures, including aorta; craniocervical region bone; nervous system; palatal shelf; and sensory organ. Orthologous to human SPON1 (spondin 1). PHENOTYPE: Mice homozygous for a null allele display increased trabecular and cortical bone mass. [provided by MGI curators] |