| Primary Identifier | MGI:98368 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 20679 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cartilage development; positive regulation of chondrocyte differentiation; and spinal cord oligodendrocyte cell differentiation. Acts upstream of or within several processes, including erythrocyte development; oligodendrocyte cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6). PHENOTYPE: Homozygotes for null mutations exhibit cardioskeletal myopathy, cardiac blockage, delayed growth, and early postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
