| Primary Identifier | MGI:2446240 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 233812 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of smoothened signaling pathway; regulation of neuron differentiation; and regulation of protein stability. Acts upstream of or within several processes, including chordate embryonic development; embryonic limb morphogenesis; and smoothened signaling pathway. Located in Golgi apparatus and ciliary membrane. Is expressed in several structures, including central nervous system; eye; heart; liver; and lung. Orthologous to human MOSMO (modulator of smoothened). PHENOTYPE: Mice homozygous for a null allele exhibit severe developmental defects, including heterotaxy, skeletal abnormalities and congenital heart defects and most die by E14.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
