Primary Identifier | MGI:1195261 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 13631 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calmodulin binding activity and elongation factor-2 kinase activity. Involved in regulation of protein autophosphorylation. Predicted to be located in dendritic spine. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in liver; lung; nervous system; and olfactory epithelium. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females. Knockout also affects behavior in response to novel objects. [provided by MGI curators] |