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Protein Coding Gene : Dctn5 dynactin 5
Primary Identifier  MGI:1891689 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  59288
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Predicted to be located in centrosome; nuclear membrane; and nucleoplasm. Predicted to be part of dynactin complex. Is expressed in ganglia and metanephros. Orthologous to human DCTN5 (dynactin subunit 5).
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit double outlet right ventricle (DORV), overriding aorta, and ventricular septal defect (VSD). Micrognathia, microcephaly/anencephaly and holoprosencephaly are also observed. [provided by MGI curators]
  • synonyms:
  • expressed sequence C78178,
  • C78178,
  • 4930427E12Rik,
  • Mutant line 315,
  • b2b315Clo,
  • MGI:1914078,
  • p25 dynactin subunit,
  • Dctn5,
  • MGI:2142326,
  • RIKEN cDNA 4930427E12 gene,
  • dynactin 5,
  • MGI:5313699
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