| Primary Identifier | MGI:1917747 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 70497 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in plasma membrane. Is expressed in facial prominence ectoderm; limb; and limb mesenchyme. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). PHENOTYPE: Mice homozygous for a knock-out allele do not develop spontaneous colitis but show a slight increase in paracellular permeability and increased susceptibility to DSS-induced colitis with rapid destruction of the inner mucus layer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
