| Primary Identifier | MGI:88319 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12478 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including B-1 B cell differentiation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of signal transduction. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency 3. Orthologous to human CD19 (CD19 molecule). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
