| Primary Identifier | MGI:1914528 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 67278 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nuclear estrogen receptor binding activity. Involved in DNA damage response; positive regulation of isotype switching to IgG isotypes; and regulation of cell cycle G2/M phase transition. Acts upstream of or within chorion development. Part of histone methyltransferase complex. Is expressed in several structures, including extraembryonic component. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). PHENOTYPE: Mice homozygous for a knock-out allele fail to undergo axial rotation and show abnormal embryonic and extraembryonic tissue development, defects in amnion, chorion and visceral yolk sac morphology, abnormal rostral-caudal body axis extension, growth arrest, and complete embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
