Primary Identifier | MGI:1338823 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 17188 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; limb; nervous system; and retina. Orthologous to human MAZ (MYC associated zinc finger protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit fetal and postnatal lethality, kidney agenesis, and impacts fertility in rare surviving mice. Mice heterozygous for this allele exhibit fetal lethality and abnormal bladder function and architecture. [provided by MGI curators] |