| Primary Identifier | MGI:1914625 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 67375 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and nicotinate-nucleotide diphosphorylase (carboxylating) activity. Predicted to be involved in NAD biosynthetic process and quinolinate catabolic process. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hindlimb; integumental system; liver; skeleton; and urinary system. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal mitochondrial morphology and physiology in peritoneal macrophages and increased proinflammatory cytokines under basal and LPS-stimulated conditions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
