Primary Identifier | MGI:2142048 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233900 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including enzyme binding activity; protein homodimerization activity; and syntaxin-1 binding activity. Predicted to be involved in positive regulation of macromolecule metabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and islets of Langerhans. Orthologous to human RNF40 (ring finger protein 40). PHENOTYPE: Colon-specific knock-out results in decreased susceptibility to induced colitis and increased bone strength. [provided by MGI curators] |