Primary Identifier | MGI:3039600 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233902 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ubiquitin-like ligase-substrate adaptor activity; unmethylated CpG binding activity; and zinc ion binding activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; and gut. Orthologous to human FBXL19 (F-box and leucine rich repeat protein 19). PHENOTYPE: Mice homozygous for a null allele stop developing around E10.5 with growth retardation, underdeveloped facial mesenchyme , hypomorphic cardiac mesemchyme, decreased body length, and small limb buds. [provided by MGI curators] |