| Primary Identifier | MGI:96607 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16409 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). PHENOTYPE: Homozygous null mice exhibit reduced staphylococcal enterotoxin-induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
