| Primary Identifier | MGI:107913 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 21843 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Is expressed in several structures, including branchial arch; central nervous system; primordial germ cell; sensory organ; and testis. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). PHENOTYPE: Homozygous null mice exhibit partial embryonic lethality and reduced postnatal survival, reduced embryonic and postnatal body weight, and male and female sterility. Infertility is owed to a substantial decrease in the survival of primordial germ cells atthe genital ridge. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
