Primary Identifier | MGI:107160 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 15373 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in ear development. Acts upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; female reproductive system; nervous system; and sensory organ. Orthologous to human HMX3 (H6 family homeobox 3). PHENOTYPE: Homozygotes for targeted null mutations exhibit hyperactivity and circling behavior, and severe vestibular defects. Mutant females are infertile due to failure of implantation. [provided by MGI curators] |