| Primary Identifier | MGI:106441 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 360216 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; and neural retina. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). PHENOTYPE: Homozygous knock-out allele leads to decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. Homozygous enzymatic inactivation leads to reduced colon mucosa thickness and increased morbidity and mortality after DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
