| Primary Identifier | MGI:2664387 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 214766 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metalloendopeptidase activity. Involved in determination of heart left/right asymmetry. Acts upstream of or within coronary vasculature development and hematopoietic progenitor cell differentiation. Predicted to be located in extracellular matrix and extracellular region. Is expressed in several structures, including brain; colon; genitourinary system; liver; and spleen. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human MMP21 (matrix metallopeptidase 21). PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit heterotaxia and congenital cardiovascular defects including d-loop transposition of the great arteries, tricupid valve atresia, and ventricular septal defect. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
