| Primary Identifier | MGI:1923734 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 76484 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cerebellar granule cell differentiation; positive regulation of protein phosphorylation; and regulation of dendrite morphogenesis. Located in dendrite and neuronal cell body. Part of guanyl-nucleotide exchange factor complex. Is expressed in lung; nervous system; neural retina; ovary; and thymus. Orthologous to human KNDC1 (kinase non-catalytic C-lobe domain containing 1). PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit altered dendritic growth and excitatory synaptic connections in cerebellar granule cells, increased grip strength, and enhanced motor coordination in balance-related tests. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
