| Primary Identifier | MGI:107825 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 11501 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cell adhesion molecule binding activity; metal ion binding activity; and metallopeptidase activity. Involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Acts upstream of or within cell-cell adhesion. Located in plasma membrane. Part of alpha9-beta1 integrin-ADAM8 complex. Is expressed in several structures, including alimentary system; hindlimb cartilage condensation; reproductive system; respiratory system; and venous system. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8). PHENOTYPE: Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
