| Primary Identifier | MGI:1921487 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 74237 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of gamma-tubulin complex. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, embryos hatch from the zona pellucida but form outgrowths with small/no ICM colony after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
