| Primary Identifier | MGI:1927665 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 64384 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NAD-dependent protein lysine deacetylase activity; protein lysine deacetylase activity; and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3). PHENOTYPE: Mice homozygous for one null allele exhibit increased systolic blood pressure while mice homozygous for another allele exhibit reduced ATP production. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
