| Primary Identifier | MGI:2141990 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 101613 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including double-stranded RNA binding activity; lipoteichoic acid binding activity; and molecular condensate scaffold activity. Involved in several processes, including defense response to other organism; regulation of defense response; and regulation of signal transduction. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity; negative regulation of signal transduction; and negative regulation of type II interferon production. Part of NLRP6 inflammasome complex. Is expressed in thymus primordium. Orthologous to human NLRP6 (NLR family pyrin domain containing 6). PHENOTYPE: Nullizygous mutations lead to altered colonic microbiota, increased susceptibility to induced colitis and/or inflammation-associated colon tumorigenesis. Homozygotes for a null allele show lower blood pressure and sex-specific changes in urine concentrating ability, cognition, and anxiety behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
