| Primary Identifier | MGI:1913391 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66141 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Involved in host-mediated suppression of symbiont invasion and response to virus. Acts upstream of or within several processes, including defense response to virus; receptor-mediated endocytosis; and type I interferon-mediated signaling pathway. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including branchial arch; egg cylinder; genitourinary system; gut; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3). PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
