| Primary Identifier | MGI:1913391 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66141 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to symbiont; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including egg cylinder; embryo ectoderm; genitourinary system; gut; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3). PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
