| Primary Identifier | MGI:104697 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17833 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in male reproductive gland or organ; nasal cavity epithelium; respiratory system; and stomach. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
