Primary Identifier | MGI:1350360 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 27027 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including defense response to protozoan; integrin-mediated signaling pathway; and negative regulation of leukocyte activation. Located in cell surface. Part of integrin alphaIIb-beta3 complex. Is expressed in several structures, including central nervous system; ganglia; immune system; placenta; and tongue. Orthologous to human TSPAN32 (tetraspanin 32). PHENOTYPE: Mice homozygous for a gene trap null mutation exhibit normal hematopoiesis, hemolytic and granulopoitic responses. B cells exhibit normal proliferative responses while T cells demonstrate enhanced proliferation upon T cell receptor stimulation. [provided by MGI curators] |