Primary Identifier | MGI:1861718 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 56843 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-activated cation channel activity; potassium channel activity; and sodium channel activity. Involved in monoatomic ion transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in dendrite; membrane; and neuronal cell body. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including ganglia; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Orthologous to human TRPM5 (transient receptor potential cation channel subfamily M member 5). PHENOTYPE: Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli. [provided by MGI curators] |