Primary Identifier | MGI:3033142 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 211578 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Predicted to be active in plasma membrane. Is expressed in genitourinary system; nervous system; and skin. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased sensitivity to cold, heat, and mechanical stimuli. Mice for another null allele exhibit dilated cardiomypathy and cardiac dysfunction. [provided by MGI curators] |