| Primary Identifier | MGI:1916947 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 69697 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables microtubule minus-end binding activity. Involved in several processes, including establishment of epithelial cell apical/basal polarity; establishment or maintenance of microtubule cytoskeleton polarity; and regulation of microtubule polymerization. Acts upstream of or within in utero embryonic development. Located in axoneme; ciliary basal body; and motile cilium. Colocalizes with microtubule minus-end. Is expressed in brain and lung epithelium. Orthologous to human CAMSAP3 (calmodulin regulated spectrin associated protein family member 3). PHENOTYPE: Homozygous null mice show variable vascular, liver, nervous system, rib and eye defects. Homozygotes for an allele disrupting microtubule binding show partial lethality, small body size, abnormal microtubule alignment in polarized epithelial cells, and multiple axon formation in hippocampal neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
