| Primary Identifier | MGI:1860493 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 54126 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including genitourinary system; liver; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit placental defects and complete lethality throughout fetal growth and development. Mice homozygous for a different null allele exhibit embryonic death around E8.5, double axis, and impaired anterior visceral endoderm cell migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
