| Primary Identifier | MGI:2444453 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234094 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). PHENOTYPE: Mice homozygous for a knock-out allele exhibit social deficits, hyperactivity, reduced anxiety-like and depression-like behavior, and increased serotonin, norepinephrine, and dopamine levels in different brain regions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
