| Primary Identifier | MGI:107658 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 15975 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables type I interferon binding activity and type I interferon receptor activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of gene expression; and response to lipopolysaccharide. Acts upstream of or within several processes, including defense response to virus; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C and immunodeficiency 106. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
