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Protein Coding Gene : Adam18 a disintegrin and metallopeptidase domain 18
Primary Identifier  MGI:105986 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  13524
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable integrin binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; male gonad development; and proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in somite. Orthologous to human ADAM18 (ADAM metallopeptidase domain 18).
PHENOTYPE: Homozygous mutant mice exhibit enhanced motor coordination during inverted screen testing when compared with that of controls. [provided by MGI curators]
  • synonyms:
  • disintegrin 3,
  • a disintegrin and metallopeptidase domain 18,
  • Dtgn3,
  • MGD-MRK-33666,
  • Adam27,
  • Adam18
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