| Primary Identifier | MGI:2142581 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234135 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H3K27 methyltransferase activity and histone H3K4 methyltransferase activity. Acts upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3). PHENOTYPE: Null mice show partial preweaning lethality, small spleen, abnormal snout, increased startle reflex and decreased exploration. Mice in which conditional deletion occurs in macrophages show increased susceptibility to vesicular stomatitis virus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
