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Protein Coding Gene : Erlin2 ER lipid raft associated 2
Primary Identifier  MGI:2387215 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  244373
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable cholesterol binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway; SREBP signaling pathway; and negative regulation of lipid biosynthetic process. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and membrane raft. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18A and hereditary spastic paraplegia 18B. Orthologous to human ERLIN2 (ER lipid raft associated 2).
  • synonyms:
  • expressed sequence C87251,
  • BC036333,
  • cDNA sequence BC036333,
  • MGI:2142881,
  • MGC:27952,
  • SPFH domain family, member 2,
  • ER lipid raft associated 2,
  • C87251,
  • Erlin2,
  • Spfh2
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Features --> Cross References

Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Mouse features --> Functions (GO terms)

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Interactions

9 Pathways

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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Literature

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