Primary Identifier | MGI:1914209 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 66959 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in mitochondrion. Is expressed in articular cartilage; limb; nervous system; neural retina; and spleen. Orthologous to human DUSP26 (dual specificity phosphatase 26). PHENOTYPE: Mice homozygous for a floxed allele activated in hepatocytes exhibit increased susceptibility to diet-induxed non-nonalcoholic fatty liver disease. [provided by MGI curators] |