| Primary Identifier | MGI:109635 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 22427 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3'-5' exonuclease activity. Involved in DNA replication and G-quadruplex DNA unwinding. Acts upstream of or within several processes, including determination of adult lifespan; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). PHENOTYPE: Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
