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Protein Coding Gene : Dusp4 dual specificity phosphatase 4
Primary Identifier  MGI:2442191 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  319520
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in several processes, including dephosphorylation; endoderm formation; and negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; olfactory epithelium; and unsegmented mesenchyme. Orthologous to human DUSP4 (dual specificity phosphatase 4).
PHENOTYPE: Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes. [provided by MGI curators]
  • synonyms:
  • dual specificity phosphatase 4,
  • MKP2,
  • MGI:1917486,
  • MGI:2142829,
  • BB104621,
  • AI844617,
  • E130306H24Rik,
  • expressed sequence AI844617,
  • MGI:2142625,
  • Dusp4,
  • 2700078F24Rik,
  • RIKEN cDNA E130306H24 gene,
  • RIKEN cDNA 2700078F24 gene,
  • expressed sequence BB104621
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