Primary Identifier | MGI:105984 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 13526 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable integrin binding activity and metalloendopeptidase activity. Acts upstream of or within prevention of polyspermy. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in genitourinary system. Orthologous to human ADAM24P (ADAM metallopeptidase domain 24, pseudogene). PHENOTYPE: Males homozygous for a targeted null mutation are subfertile and produce an increased number of polyspermic embryos at the pronuclear stage. Female homozygotes show normal fertility. [provided by MGI curators] |