| Primary Identifier | MGI:99828 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 11988 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport and regulation of macrophage activation. Acts upstream of or within several processes, including macrophage activation; nitric oxide biosynthetic process; and nitric oxide production involved in inflammatory response. Located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SLC7A2 (solute carrier family 7 member 2). PHENOTYPE: Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
