Primary Identifier | MGI:1277958 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 18536 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable molecular adaptor activity. Involved in several processes, including interkinetic nuclear migration; microtubule anchoring; and protein localization to centrosome. Acts upstream of or within several processes, including microtubule anchoring at centrosome; neuronal stem cell population maintenance; and social behavior. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). PHENOTYPE: Haploinsufficient mice show a reduced brain size, behavioral impairment to social stimulus and reduced rearing in the open field test. [provided by MGI curators] |