| Primary Identifier | MGI:2156367 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 142980 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). PHENOTYPE: Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
