| Primary Identifier | MGI:109124 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 22341 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of lymphangiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; morphogenesis of embryonic epithelium; and positive regulation of glial cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C). PHENOTYPE: Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
