| Primary Identifier | MGI:1913066 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 59009 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). PHENOTYPE: Mice homozygous for a null allele exhibit decreased dendritic spine length and density, impaired spatial learning and reference memory, impaired contextual conditioning, increased digging, impaired nest building, decreased social investigation, reduced vocalization, decreased excitatory postsynaptic current amplitude, and reduced long term potentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
